Marvi Memon

Wishaw University Hospital<br>United Kingdom

Abstract Title: Pregnancy outcomes in women with Pre-existing diabetes (type1,type 2 diabetes mellitus).

Biography:

Marvi Memon working as Senior clinical fellow I have done MRCOG in year 2023. I have done workin research and publications

Research Interest:

Abstract Pre-existing diabetes in pregnancy, type 1 and type 2 diabetes are associated with adverse neonatal outcomes and increased rates of caesarean sections. Methods: We studied pregnancy outcomes associated with pre- diabetes in 36 women who booked their pregnancy in the National Maternity Hospital in Scotland, between 2023 and 2024.

Results: Fifteen women (41.6%) had type 2 diabetes mellitus, and 21 women (58%) had type 1 diabetes mellitus. Women with type 2 diabetes mellitus were older (36 vs. 34 years, p 0.02) and had a higher BMI (32.6 vs. 26.2 kg/m2, p 0.00). Duration of diabetes mellitus in type 1 and type 2 was 14.7 and 5.7 years, respectively, and mean HbA1c in type 2 diabetes mellitus at booking was 46.5 mmol/mol (7.2%) and in type 1 diabetes mellitus was 55.3 mmol/mol (6.3%). Less no of women attended preconception counselling nine women (25%). More Progression of Retinopathy six women (26%) was observed in women with type1 diabetes mellitus mainly during second trimester. Twelve women (57%) with type 1 diabetes mellitus used continuous subcutaneous insulin infusion. Twelve woman (80%) with type 2 diabetes mellitus were treated with insulin plus Metformin. In our cohort, 65% had a caesarean delivery. Offspring of patients with multiple dose injections were lighter (3.58 kg) than infants of continuous subcutaneous insulin infusion-treated patients (3.75 kg). More preterm births were observed in woman with type1 diabetes mellitus (75%). More elective and emergency caesarean sections (47.5%) were observed in the type1 diabetes (33.3,14.2%) respectively. Women treated with continuous subcutaneous insulin infusion had a higher rate of miscarriage (33.3%). Increased neonatal unit admission seven (33.3%) for preterm babies born to women with type1 diabetes.

Conclusion: Women in our study with pre-existing diabetes were overweight, were older and had long-standing diabetes mellitus. Our patients with type 2 diabetes had a higher BMI, were older, had a shorter duration of diabetes mellitus and had better diabetes control compared to women with type 1 diabetes. Women treated with continuous subcutaneous insulin infusion had a higher rate of miscarriage and preterm birth. The initial inadequate diabetes control was significantly improved during pregnancy